Synthesis and characterization of poly(antioxidant β-amino esters) for controlled release of polyphenolic antioxidants

• Published in: Acta biomaterialia Vol. 8; no. 7; pp. 2529 - 2537
• Main Authors: Wattamwar, Paritosh P., Biswal, Dipti, Cochran, David B., Lyvers, Adam C., Eitel, Richard E., Anderson, Kimberly W., Hilt, J. Zach, Dziubla, Thomas D.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2012
• Subjects: Acrylates - chemistry; antioxidant activity; Antioxidant polymers; antioxidants; Antioxidants - administration & dosage; Antioxidants - pharmacology; Biocompatibility; biocompatible materials; biodegradability; Cell Death - drug effects; Curcumin; Curcumin - chemistry; Curcumin - pharmacology; Cytoprotection - drug effects; Delayed-Action Preparations; endothelial cells; esters; free radicals; Human Umbilical Vein Endothelial Cells; Humans; hydrocolloids; Hydrogels - chemical synthesis; Hydrogels - chemistry; Hydrogen Peroxide - pharmacology; inflammation; Magnetic Resonance Spectroscopy; Oxidative stress; Oxidative Stress - drug effects; polymers; Polymers - chemical synthesis; Polymers - chemistry; Polyphenols; Polyphenols - administration & dosage; Polyphenols - pharmacology; quercetin; Quercetin - chemistry; Quercetin - pharmacology; Spectroscopy, Fourier Transform Infrared; Polyphenols; Oxidative stress; Biocompatibility; Curcumin; Antioxidant polymers
• ISSN: 1742-7061; 1878-7568
• DOI: 10.1016/j.actbio.2012.03.022

Attenuation of cellular oxidative stress, which plays a central role in biomaterial-induced inflammation, provides an exciting opportunity to control the host tissue response to biomaterials. In the case of biodegradable polymers, biomaterial-induced inflammation is often a result of local accumulation of polymer degradation products, hence there is a need for new biomaterials that can inhibit this response. Antioxidant polymers, which have antioxidants incorporated into the polymer backbone, are a class of biomaterials that, upon degradation, release active antioxidants, which can scavenge free radicals and attenuate oxidative stress, resulting in improved material biocompatibility. In this work, we have synthesized poly(antioxidant β-amino ester) (PAβAE) biodegradable hydrogels of two polyphenolic antioxidants, quercetin and curcumin. The degradation characteristics of PAβAE hydrogels and the antioxidant activity of PAβAE degradation products were studied. Treatment of endothelial cells with PAβAE degradation products protected cells from hydrogen-peroxide-induced oxidative stress.