Neuroendocrine Cell Hyperplasia of Infancy: Diagnosis With High-Resolution CT

• Published in: American journal of roentgenology (1976) Vol. 194; no. 1; pp. 238 - 244
• Main Authors: Brody, Alan S, Guillerman, R. Paul, Hay, Thomas C, Wagner, Brandie D, Young, Lisa R, Deutsch, Gail H, Fan, Leland L, Deterding, Robin R
• Format: Journal Article
• Language: English
• Published: Reston, VA Am Roentgen Ray Soc 01.01.2010; American Roentgen Ray Society
• Subjects: Biological and medical sciences; Biopsy; Diagnosis, Differential; Female; Humans; Hyperplasia; Infant; Lung - pathology; Lung Diseases, Interstitial - diagnostic imaging; Male; Medical sciences; Neurosecretory Systems - cytology; Pneumology; Respiratory system : syndromes and miscellaneous diseases; Retrospective Studies; Tomography, X-Ray Computed - methods; Human; Lung disease; Neuroendocrine cell; High resolution; Radiodiagnosis; Tachypnea; Respiratory disease; Hyperplasia; Infant; Sensitivity; Specificity; Interstitial pneumonitis; Medical imagery; Computerized axial tomography; Diagnosis; Child
• ISSN: 0361-803X; 1546-3141
• DOI: 10.2214/AJR.09.2743

Neuroendocrine cell hyperplasia of infancy is a form of childhood interstitial lung disease originally reported as persistent tachypnea of infancy. Reports of small series of cases and anecdotal experience have suggested that this disorder may have a consistent CT pattern. The purpose of this study was to review the CT findings in children with neuroendocrine cell hyperplasia of infancy to determine the findings at high-resolution CT, the diagnostic accuracy of CT compared with biopsy, and interrater reliability. Images from 23 CT examinations of children with biopsy-proven neuroendocrine cell hyperplasia of infancy and six CT examinations of children with other childhood interstitial lung diseases were reviewed by two pediatric radiologists with special expertise in thoracic imaging. Identifying digital data were removed, and images were reviewed without clinical data. A CT assessment form was completed for each patient. Ground-glass opacification was the most common finding in patients with neuroendocrine cell hyperplasia of infancy. The right middle lobe and lingula were most commonly involved. Air trapping with a mosaic pattern was the second most common finding. Interrater reliability was very good with a kappa value of 0.93. The sensitivity and specificity of CT in the diagnosis of neuroendocrine cell hyperplasia of infancy were at least 78% and 100%. Neuroendocrine cell hyperplasia of infancy can have a characteristic appearance on high-resolution CT scans, the imaging findings being useful in differentiating neuroendocrine cell hyperplasia of infancy from other types of childhood interstitial lung disease. The appearance aids radiologists in suggesting a specific diagnosis but does not exclude this diagnosis; in 17-22% of cases, the readers in this study did not suggest the diagnosis of neuroendocrine cell hyperplasia of infancy when it was present.