A clinical and histopathologic study of granulomatous rosacea

• Published in: Journal of the American Academy of Dermatology Vol. 25; no. 6; pp. 1038 - 1043
• Main Authors: Helm, Klaus F., Menz, Jennifer, Gibson, Lawrence E., Dicken, Charles H.
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.12.1991; Elsevier
• Subjects: Aged; Aged, 80 and over; Biological and medical sciences; Blister - pathology; Dermatology; Elastic Tissue - pathology; Erythema - pathology; Female; Folliculitis - pathology; Granuloma - drug therapy; Granuloma - pathology; Histiocytes - pathology; Humans; Lymphocytes - pathology; Male; Medical sciences; Middle Aged; Retrospective Studies; Rosacea - drug therapy; Rosacea - pathology; Single-Blind Method; Skin - blood supply; Skin - pathology; Skin Aging - pathology; Telangiectasis - pathology; Human; Pathology; Granuloma; Skin disease; Clinical investigation; Acne rosacea
• ISSN: 0190-9622; 1097-6787
• DOI: 10.1016/0190-9622(91)70304-K

A retrospective clinical and histopathologic study of 53 patients with granulomatous rosacea was undertaken. The patients had a broad clinical spectrum of lesions that ranged from primarily erythema to papulonodular lesions. Extrafacial lesions occurred in 15% of patients. Histologic examination showed mixed lymphohistiocytic inflammation (primarily lymphocytic inflammation in 40% of patients and primarily histiocytic with a few giant cells in 34%), epithelioid granulomas in 11% of patients, and epithelioid granulomas with caseation necrosis in 11%. Most patients had a good response to oral antibiotic therapy. Granulomatous rosacea is not a distinct disease but can be regarded and treated as a subtype of rosacea.