Strawberry consumption alleviates doxorubicin-induced toxicity by suppressing oxidative stress

• Published in: Food and chemical toxicology Vol. 94; pp. 128 - 137
• Main Authors: Giampieri, Francesca, Alvarez-Suarez, Jose M., Gasparrini, Massimiliano, Forbes- Hernandez, Tamara Y., Afrin, Sadia, Bompadre, Stefano, Rubini, Corrado, Zizzi, Antonio, Astolfi, Paola, Santos-Buelga, Celestino, González-Paramás, Ana M., Quiles, Josè L., Mezzetti, Bruno, Battino, Maurizio
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2016
• Subjects: Animals; Antibiotics, Antineoplastic - toxicity; Antioxidants - metabolism; Bioactive compounds; Biomarkers - blood; Body Weight; Doxorubicin; Doxorubicin - toxicity; Fragaria; Liver - drug effects; Liver - pathology; Male; Mitochondrial functionality; Organ Size; Oxidative Stress; Rats; Rats, Wistar; Strawberry; Oxidative stress; ACYs; CoQ; ALP; EPR; OGG1; TPC; ALT; PPH; CDNB; Doxorubicin; TFC; Bioactive compounds; Strawberry; FRAP; GSH; Pg-3-glc; NBT; Mitochondrial functionality; AST; Cy-3-glc; GST; SOD; GR; Dox; FOX; GPx; vit A; TEAC; vit E; CAT; TAC; SEM; OCR
• ISSN: 0278-6915; 1873-6351
• DOI: 10.1016/j.fct.2016.06.003

Doxorubicin (Dox), one of the most used chemotherapeutic agents, is known to generate oxidative stress and block DNA synthesis, which result in severe dose-limiting toxicity. A strategy to protect against Dox toxic effects could be to use dietary antioxidants of which fruits and vegetable are a rich source. In this context, strawberry consumption is associated with the maintenance of good health and the prevention of several diseases, thanks to the antioxidant capacities of its bioactive compounds. The aim of the present study was to evaluate the protective effects of strawberry consumption against oxidative stress induced by Dox in rats. Animals were fed with strawberry enriched diet (15% of the total calories) for two months and Dox (10 mg/kg; i.p.) was injected at the end of the experimental period. Strawberry consumption significantly inhibited ROS production and oxidative damage biomarkers accumulation in plasma and liver tissue and alleviated histopathological changes in rat livers treated with Dox. The reduction of antioxidant enzyme activities was significantly mitigated after strawberry consumption. In addition, strawberry enriched diet ameliorated liver mitochondrial antioxidant levels and functionality. In conclusion, strawberry intake protects against Dox-induced toxicity, at plasma, liver and mitochondrial levels thanks to its high contents of bioactive compounds. [Display omitted] •Strawberry consumption protects against Dox-induced oxidative stress in rats.•Strawberry intake improves antioxidant defences.•Strawberry intake ameliorates mitochondrial antioxidant status and functionality.