Efficient one-step synthesis of 3-aryl-2-pyridones from 6-aryl-1,2,4-triazin-5-ones

An efficient method for the synthesis of substituted 2-pyridones based on the aza-Diels–Alder reaction of 1,2,4-triazin-5-ones and dienophiles, 2,5-norbornadiene and 4-(cyclopent-1-en-1-yl)morpholine, is proposed.

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Bibliographic Details
Published inChemistry of heterocyclic compounds (New York, N.Y. 1965) Vol. 55; no. 10; pp. 985 - 988
Main Authors Savchuk, Maria I., Shtaitz, Yaroslav K., Kopchuk, Dmitry S., Zyryanov, Grigory V., Eltsov, Oleg S., Pospelova, Tatiana А., Rusinov, Vladimir L., Chupakhin, Oleg N.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.10.2019
Springer Nature
Springer
Springer Nature B.V
Subjects
Aromatic compounds
Chemistry
Chemistry and Materials Science
Chemistry, Organic
Diels-Alder reaction
Morpholine
Organic Chemistry
Perampanel
Pharmacy
Physical Sciences
Science & Technology
autoclave
substitution
1,2,4-triazin-5-one
2,2'-bipyridine
2-pyridone
nucleophilic
aza-Diels–Alder reaction
1,2,4-TRIAZINES
SUBSTITUTION
nucleophilic ipso-substitution
aza-Diels-Alder reaction
2-PYRIDONES
DIELS-ALDER REACTION
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Summary:An efficient method for the synthesis of substituted 2-pyridones based on the aza-Diels–Alder reaction of 1,2,4-triazin-5-ones and dienophiles, 2,5-norbornadiene and 4-(cyclopent-1-en-1-yl)morpholine, is proposed.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-019-02566-7