New insights into the roles of CHOP-induced apoptosis in ER stress

• Published in: Acta biochimica et biophysica Sinica Vol. 46; no. 8; pp. 629 - 640
• Main Authors: Li, Yiming, Guo, Yunshan, Tang, Juan, Jiang, Jianli, Chen, Zhinan
• Format: Journal Article
• Language: English
• Published: China 01.08.2014
• Subjects: Apoptosis - physiology; EBP; Endoplasmic Reticulum - metabolism; Gene Expression Profiling; Humans; Stress, Physiological; Transcription Factor CHOP - genetics; Transcription Factor CHOP - physiology; Transcription, Genetic; 内质网应激; 神经变性疾病; 细胞凋亡; 自适应机制; 蛋白质; 诱导剂; 转录因子

Endoplasmic reticulum stress （ER stress） is triggered due to a loss of homeostasis in the ER, resulting in accu- mulation of misfoided proteins in the ER lumen. ER stress activates a series of adaptive mechanisms known as the unfolded protein response. Perturbation of the ER is a powerful inducer of...