New insights into the roles of CHOP-induced apoptosis in ER stress

Endoplasmic reticulum stress （ER stress） is triggered due to a loss of homeostasis in the ER, resulting in accu- mulation of misfoided proteins in the ER lumen. ER stress activates a series of adaptive mechanisms known as the unfolded protein response. Perturbation of the ER is a powerful inducer of...

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Published inActa biochimica et biophysica Sinica Vol. 46; no. 8; pp. 629 - 640
Main Authors Li, Yiming, Guo, Yunshan, Tang, Juan, Jiang, Jianli, Chen, Zhinan
Format Journal Article
LanguageEnglish
Published China 01.08.2014
Subjects
Apoptosis - physiology
EBP
Endoplasmic Reticulum - metabolism
Gene Expression Profiling
Humans
Stress, Physiological
Transcription Factor CHOP - genetics
Transcription Factor CHOP - physiology
Transcription, Genetic
内质网应激
神经变性疾病
细胞凋亡
自适应机制
蛋白质
诱导剂
转录因子
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Summary:Endoplasmic reticulum stress （ER stress） is triggered due to a loss of homeostasis in the ER, resulting in accu- mulation of misfoided proteins in the ER lumen. ER stress activates a series of adaptive mechanisms known as the unfolded protein response. Perturbation of the ER is a powerful inducer of the transcription factor C/EBP hom- ologous protein （CHOP）. Although it has been proved that excessive or adverse stress to the ER triggers apoptosis, the specific mechanisms underlying these processes induced by CHOP remain unclear. By now, CHOP-induced apoptosis in ER stress has been implicated in numerous human dis- eases, such as neurodegenerative diseases, diabetes, ische- mic diseases, tumor, and so on. In this review, we summarized the current understanding of the roles of CHOP in the development of several diseases from the laboratory to the clinic.
Bibliography:31-1940/Q
CHOP; ER stress; apoptosis; transcriptionalfactor; gene expression regulation; signal transduction;diseases
Endoplasmic reticulum stress （ER stress） is triggered due to a loss of homeostasis in the ER, resulting in accu- mulation of misfoided proteins in the ER lumen. ER stress activates a series of adaptive mechanisms known as the unfolded protein response. Perturbation of the ER is a powerful inducer of the transcription factor C/EBP hom- ologous protein （CHOP）. Although it has been proved that excessive or adverse stress to the ER triggers apoptosis, the specific mechanisms underlying these processes induced by CHOP remain unclear. By now, CHOP-induced apoptosis in ER stress has been implicated in numerous human dis- eases, such as neurodegenerative diseases, diabetes, ische- mic diseases, tumor, and so on. In this review, we summarized the current understanding of the roles of CHOP in the development of several diseases from the laboratory to the clinic.
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ISSN:1672-9145
1745-7270
1745-7270
DOI:10.1093/abbs/gmu048