Morphology of occlusive coronary lesions during acute myocardial infarction: An angiographic and clinical analysis

In an attempt to identify angiographic and clinical predictors of reperfusion, 42 patients who received intracoronary streptokinase during the early phase of myocardial infarction were analyzed. The different morphologies (regular and irregular) of the occlusive lesions did not show a significant re...

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Published inThe American heart journal Vol. 113; no. 1; pp. 84 - 89
Main Authors Saenz, Carlos B., Rogers, William J., Whitlow, Patrick L., Baxley, William A., Hood, William P., Katholi, Charles R., Soto, Benigno
Format Journal Article
LanguageEnglish
Published New York, NY Mosby, Inc 1987
Elsevier
Subjects
Adult
Aged
Biological and medical sciences
Cardiology. Vascular system
Coronary Angiography
Coronary heart disease
Female
Heart
Humans
Male
Medical sciences
Middle Aged
Myocardial Infarction - drug therapy
Perfusion
Streptokinase - therapeutic use
Human
Prognosis
Infarct
Radiodiagnosis
Acute
Coronary artery
Cardiovascular disease
Coronary arteriography
Coronary heart disease
Local administration
Chemotherapy
Streptokinase
Myocardium
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Summary:In an attempt to identify angiographic and clinical predictors of reperfusion, 42 patients who received intracoronary streptokinase during the early phase of myocardial infarction were analyzed. The different morphologies (regular and irregular) of the occlusive lesions did not show a significant relation with the response (reperfusion vs nonreperfusion) to intracoronary streptokinase; neither did the presence of angiographically visualized thrombus in the infarct-related artery favor reperfusion. Among the clinical variables analyzed (previous myocardial infarction, previous angina, diabetes mellitus, hypertension, use of tobacco, and hyperlipidemia), a history of previous angina was significantly related to absence of reperfusion ( p = 0.001). Although the presence of thrombus showed a trend toward reperfusion ( p = 0.1), overall, our angiographic observations did not contribute to predicting the response to streptokinase. Further studies are needed to identify morphologic criteria favoring reperfusion and select groups of patients most likely to benefit from it.
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ISSN:0002-8703
1097-6744
DOI:10.1016/0002-8703(87)90013-5