Lipids, lipoproteins and other coronary risk factors in Chinese male survivors of myocardial infarction

• Published in: International journal of cardiology Vol. 39; no. 3; pp. 195 - 202
• Main Authors: Woo, J., Ho, S.C., Wong, S.L., Woo, K.S., Tse, C.Y., Chan, K.K., Kay, C.S., Mak, W.P., Cheung, K.O., Lam, C.W.K., Donnan, S.P.B.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.06.1993; Elsevier Science
• Subjects: Apolipoprotein; Apolipoprotein A-I - analysis; Apolipoproteins B - blood; Biological and medical sciences; Cardiology. Vascular system; Case-Control Studies; China - ethnology; Chinese; Coronary heart disease; Diabetes Complications; Heart; Hong Kong - epidemiology; Humans; Hyperlipidemias - blood; Hyperlipidemias - complications; Hypertension - complications; Lipids; Lipids - blood; Lipoprotein; Lipoproteins - blood; Logistic Models; Male; Medical sciences; Myocardial infarction; Myocardial Infarction - diagnosis; Myocardial Infarction - epidemiology; Myocardial Infarction - ethnology; Myocardial Infarction - etiology; Obesity - complications; Odds Ratio; Risk Factors; Smoking - adverse effects; Survival Rate; Asia; China; Hong Kong; Myocardial infarction; Lipids; Chinese; Lipoprotein; Apolipoprotein; Risk factors; Human; Infarct; Sex; Cardiovascular disease; Metabolic diseases; Male; Apolipoproteins; Coronary heart disease; Survival; Risk factor; Myocardium; Serum
• ISSN: 0167-5273; 1874-1754
• DOI: 10.1016/0167-5273(93)90038-I

Objective: To assess the importance of an abnormal lipid profile as a risk factor in relation to non-biochemical risk factors, and to define the risk levels for lipid, lipoprotein and apolipoprotein in a Chinese population. Patients and Methods: Serum lipids, lipoproteins, apolipoproteins and other cardiovascular risk factors were studied in 89 Chinese men 3 months after acute myocarial infarction and 56 controls. Results: Cases had higher mean total cholesterol (TC), LDL- and VLDL-cholesterol, triglycerides and apolipoprotein B (Apo B), and lower mean HDL-cholesterol and apolipoprotein AI (Apo AI). Mean BMI was also higher, as was the prevalence of smokers and subjects with a history of hypertension. In univariate analysis, the odds ratios for TG ≥ 1.6 mmol/l, LDL-cholesterol ≥ 4.1 mmol/l, VLDL-cholesterol ≥ 0.73 mmol/l, Apo B ≥ 104 mg/dl were of the same order of magnitude as being a current smoker, having a BMI ≥ 24.3 kg/m 2, and a history of a hypertension. High HDL-cholesterol (≥ 1.39 mmol/l) and Apo AI (≥ 139 mg/dl) were protective factors. The odds ratios for successively higher quartile values of cholesterol were not statistically significant. Multiple logistic regression identified smoking habit, history of hypertension, obesity, high Apo B and low Apo AI concentrations as independent risk factors for myocardial infarction. Conclusions: In a Chinese population, low serum Apo AI and high Apo B are risk factors for myocardial infarction of a comparable magnitude to smoking, hypertension and obesity.