Aaptamine Alkaloids from the Vietnamese Sponge Aaptos sp

A series of aaptamines, including one new alkaloid (1), were isolated from the marine sponge Aaptos sp. collected in Vietnamese waters. The structure of 1 was elucidated using NMR and HRESIMS, as well as by chemical transformation of 1 to the previously known aaptamine and established as 3-N-morphol...

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Published inNatural product communications Vol. 4; no. 8; pp. 1085 - 1088
Main Authors Shubina, Larisa K., Kalinovsky, Anatoly I., Fedorov, Sergey N., Radchenko, Oleg S., Denisenko, Vladimir A., Dmitrenok, Pavel S., Dyshlovoy, Sergey A., Krasokhin, Vladimir B., Stonik, Valentin A.
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.08.2009
Subjects
Alkaloids - chemistry
Alkaloids - isolation & purification
Animals
Magnetic Resonance Spectroscopy
Mass Spectrometry
Models, Molecular
Naphthyridines - chemistry
Naphthyridines - isolation & purification
Porifera - chemistry
Seawater
Vietnam
Vietnam
1D and 2D NMR
Aaptamine-type alkaloids
Aaptos sp
cancer-preventive activity
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Summary:A series of aaptamines, including one new alkaloid (1), were isolated from the marine sponge Aaptos sp. collected in Vietnamese waters. The structure of 1 was elucidated using NMR and HRESIMS, as well as by chemical transformation of 1 to the previously known aaptamine and established as 3-N-morpholinyl-9-demethyl(oxy)aaptamine. The isolated compounds showed a potential cancer preventive activity.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X0900400813