Prevention of ethanol-induced gastric damage by the imidazobenzodiazepines Ro 15-4513 and Ro 15-3505 in rats
The protective effects of the imidazobenzodiazepines Ro 15-4513 and Ro 15-3505 against ethanol-induced gastric damage were investigated. Gastric lesions were induced in rats by the oral administration of 1 ml of absolute ethanol. Ro 15-4513 (2.5–10 mg/kg, IP) or Ro 15-3505 (5–20 mg/kg, IP), administ...
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Published in | Pharmacology, biochemistry and behavior Vol. 45; no. 3; pp. 597 - 599 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
New York, NY
Elsevier Inc
01.07.1993
Elsevier Science |
Subjects | |
Online Access | Get full text |
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Summary: | The protective effects of the imidazobenzodiazepines Ro 15-4513 and Ro 15-3505 against ethanol-induced gastric damage were investigated. Gastric lesions were induced in rats by the oral administration of 1 ml of absolute ethanol. Ro 15-4513 (2.5–10 mg/kg, IP) or Ro 15-3505 (5–20 mg/kg, IP), administered 30 min before ethanol, protected against ethanol-induced gastric damage. The protective effects of these compounds were blocked by the benzodiazepine antagonist, flumazenil (10 mg/kg, IP). These results present evidence for the involvement of the GABA-benzodiazepine receptor complex in the pathogenesis of ethanol-induced gastric damage. |
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ISSN: | 0091-3057 1873-5177 |
DOI: | 10.1016/0091-3057(93)90512-R |