Prevention of ethanol-induced gastric damage by the imidazobenzodiazepines Ro 15-4513 and Ro 15-3505 in rats

• Published in: Pharmacology, biochemistry and behavior Vol. 45; no. 3; pp. 597 - 599
• Main Authors: Najim, Rafid A., Karim, Kassim H.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.07.1993; Elsevier Science
• Subjects: Alcoholism and acute alcohol poisoning; Animals; Azides - antagonists & inhibitors; Azides - therapeutic use; Benzodiazepines - antagonists & inhibitors; Benzodiazepines - therapeutic use; Benzodiazepinones - antagonists & inhibitors; Benzodiazepinones - therapeutic use; Biological and medical sciences; Ethanol; Flumazenil; Flumazenil - pharmacology; Gastric damage; Male; Medical sciences; Rats; Rats, Wistar; Ro 15-3505; Ro 15-4513; Stomach Ulcer - chemically induced; Stomach Ulcer - prevention & control; Toxicology; Gastric damage; Rats; Ro 15-3505; Flumazenil; Ethanol; Ro 15-4513; Intraperitoneal administration; Rat; Psychotropic; Toxicity; Rodentia; Oral administration; Prevention; Vertebrata; Chemotherapy; Mammalia; Treatment; Inverse agonist; Animal; Digestive diseases; Benzodiazepine derivatives; Mucosa disease; Gastric disease
• ISSN: 0091-3057; 1873-5177
• DOI: 10.1016/0091-3057(93)90512-R

The protective effects of the imidazobenzodiazepines Ro 15-4513 and Ro 15-3505 against ethanol-induced gastric damage were investigated. Gastric lesions were induced in rats by the oral administration of 1 ml of absolute ethanol. Ro 15-4513 (2.5–10 mg/kg, IP) or Ro 15-3505 (5–20 mg/kg, IP), administered 30 min before ethanol, protected against ethanol-induced gastric damage. The protective effects of these compounds were blocked by the benzodiazepine antagonist, flumazenil (10 mg/kg, IP). These results present evidence for the involvement of the GABA-benzodiazepine receptor complex in the pathogenesis of ethanol-induced gastric damage.