Role of cadmium and magnesium in pathogenesis of idiopathic dilated cardiomyopathy

• Published in: The American journal of cardiology Vol. 58; no. 3; pp. 364 - 366
• Main Authors: Smetana, Ronald H., Glogar, Dietmar H.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.08.1986; Elsevier
• Subjects: Adolescent; Adult; Aged; Biological and medical sciences; Cadmium - blood; Cadmium - urine; Cardiology. Vascular system; Cardiovascular Diseases - etiology; Cardiovascular Diseases - physiopathology; Dilatation, Pathologic - etiology; Female; Heart; Heart Ventricles; Hemodynamics; Humans; Magnesium - blood; Magnesium - urine; Magnesium Deficiency - complications; Male; Medical sciences; Middle Aged; Myocarditis. Cardiomyopathies; Prospective Studies; Smoking; Human; Cadmium; Metabolic disorder; Congestive hypertrophic cardiomyopathy; Cardiovascular disease; Inorganic element; Myocardial disease; Hypomagnesemia; Blood
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/0002-9149(86)90082-2

Many investigators have focused attention on the deviation of essential metal profile and the occurrence of pathologic cardiovascular effects. Magnesium deficiency 1 and cadmium excess 2 are suspected to be involved in the pathogenesis of coronary heart disease and sudden death. In idiopathic dilated cardiomyopathy (IDC), the role of cobalt 3 and selenium 4 as etiologic factors is well documented. No report exists concerning an association between cadmium concentration and clinical data in IDC, whereas magnesium loss appears to be a factor in pathogenesis of arrhythmias. 5