Fluoroquinolones

The fluoroquinolone class of antimicrobial agents has expanded dramatically in the last 5 years and will continue to grow over the next decade. This article discusses the newer fluoroquinolones in detail, including pharmacokinetics, pharmacodynamics, safety, and drug interactions, and the spectrum o...

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Bibliographic Details
Published inInfectious disease clinics of North America Vol. 14; no. 2; p. 489
Main Authors O'Donnell, J A, Gelone, S P
Format Journal Article
LanguageEnglish
Published United States 01.06.2000
Subjects
Anti-Infective Agents - pharmacokinetics
Anti-Infective Agents - pharmacology
Anti-Infective Agents - therapeutic use
Bacterial Infections - drug therapy
Drug Resistance, Microbial
Fluoroquinolones
Gram-Negative Bacteria - drug effects
Gram-Positive Bacteria - drug effects
Humans
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Summary:The fluoroquinolone class of antimicrobial agents has expanded dramatically in the last 5 years and will continue to grow over the next decade. This article discusses the newer fluoroquinolones in detail, including pharmacokinetics, pharmacodynamics, safety, and drug interactions, and the spectrum of in vitro activity. Newer agents are compared and contrasted with the older ones, particularly ciprofloxacin and ofloxacin, and problems with liver toxicity and trovafloxacin are described. Finally, appropriate use of the fluoroquinolones is discussed, including their role in the treatment of urinary tract infections, sexually transmitted diseases, gastrointestinal infections, osteomyelitis, and respiratory tract infections.
ISSN:0891-5520
DOI:10.1016/S0891-5520(05)70260-9