Histidinylated linear PEI: a new efficient non-toxic polymer for gene transfer

A series of linear polyethylenimine (lPEI) substituted with histidine residue (His-lPEI) was synthesized using the Michael reaction in order to provide new highly efficient vectors for gene therapy applications (up to 95% of transfected cells) with remarkable low cytotoxicity compared to lPEI-based...

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Published inChemical communications (Cambridge, England) Vol. 47; no. 46; pp. 12547 - 12549
Main Authors Bertrand, Emilie, Goncalves, Cristine, Billiet, Ludivine, Gomez, Jean Pierre, Pichon, Chantal, Cheradame, Herve, Midoux, Patrick, Guegan, Philippe
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 14.12.2011
Royal Society of Chemistry
Subjects
Biochemistry, Molecular Biology
Chemistry
Chemistry, Multidisciplinary
Drug Carriers
Drug Carriers - chemistry
Drug Carriers - toxicity
HEK293 Cells
HeLa Cells
Histidine
Histidine - chemistry
Humans
Life Sciences
Physical Sciences
Polyethyleneimine
Polyethyleneimine - chemistry
Polyethyleneimine - toxicity
Science & Technology
Transfection
Transfection - methods
DERIVATIVES
POLYETHYLENIMINE
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Summary:A series of linear polyethylenimine (lPEI) substituted with histidine residue (His-lPEI) was synthesized using the Michael reaction in order to provide new highly efficient vectors for gene therapy applications (up to 95% of transfected cells) with remarkable low cytotoxicity compared to lPEI-based polyplexes.
ISSN:1359-7345
1364-548X
DOI:10.1039/c1cc15716g