A self-coated hollow mesoporous silica nanoparticle for tumor targeting and chemo-photothermal therapy

• Published in: Journal of materials science Vol. 57; no. 10; pp. 6013 - 6025
• Main Authors: Xu, Qingni, Chang, Cong, Wang, Xuelian, Li, Chaohua, Chen, Yuqi, Zhang, Yueli, Yin, Mengqi, Li, Yuyang, Xiong, Bei, Lu, Bo
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.03.2022; Springer; Springer Nature B.V
• Subjects: Cancer; Characterization and Evaluation of Materials; Chemistry and Materials Science; Chemotherapy; Classical Mechanics; Crystallography and Scattering Methods; Doxorubicin; Drug delivery systems; Drugs; Health aspects; Hyaluronic acid; Lasers; Materials for Life Sciences; Materials Science; Nanoparticles; Photothermal conversion; Polymer Sciences; Silica; Silicon dioxide; Solid Mechanics; Tumors; Vehicles
• ISSN: 0022-2461; 1573-4803
• DOI: 10.1007/s10853-022-07020-2

Chemotherapy combined with photothermal therapy, a promising strategy for cancer treatment, has a high potential to control drug release and improve therapeutic efficacy. Inspired by this, a pH/NIR dual-responsive drug delivery system (DOX/HMSN@PDA-HA nanoparticles, simplified as DHPH NPs) based on hollow mesoporous silica nanoparticles (HMSNs) was designed for targeted therapy of tumor, by self-coating polydopamine-modified hyaluronic acid (HA-PDA) layer. Doxorubicin (DOX) was loaded into HMSNs for chemotherapy, while HA-PDA coating acted as photothermal therapy agent with tumor-targeted capability. Characterizations suggest that DHPH nanoparticles have been successfully constructed with excellent drug loading capacity (36.91%) and satisfactory photothermal conversion efficiency (25.74%). Furthermore, in vitro results indicate that DHPH nanoparticles could precisely target human hepatocellular liver carcinoma cells and effectively suppress the tumor cells growth under 808 nm laser irradiation (2 W cm −2 ). Therefore, this study presents a feasible strategy for developing efficient platform for tumor-targeted chemo-photothermal therapy.