A remote system for the synthesis of copper-62 labeled Cu(PTSM)

The construction and performance of a remote system is described for the synthesis of 62Cu-labeled pyruvaldehyde bis( N 4-methylthiosemicarbazonato)copper(II), [ 62Cu]Cu(PTSM), a positron-emitting radiopharmaceutical for perfusion imaging. The remote system allows the shielded synthesis and purifica...

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Published inInternational journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes Vol. 42; no. 3; pp. 317 - 320
Main Authors Mathias, Carla J., Margenau, William H., Brodack, James W., Welch, Michael J., Green, Mark A.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier B.V 1991
Pergamon
Subjects
Chemistry
Copper Radioisotopes
Equipment Design
Exact sciences and technology
Inorganic chemistry and origins of life
Isotope Labeling - instrumentation
Organometallic Compounds - chemical synthesis
Perfusion
Preparations and properties
Thiosemicarbazones - chemical synthesis
Tomography, Emission-Computed
Organic ligand
Thiosemicarbazone
Copper Complexes
Labelled compound
Copper Isotopes
Tracers
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Summary:The construction and performance of a remote system is described for the synthesis of 62Cu-labeled pyruvaldehyde bis( N 4-methylthiosemicarbazonato)copper(II), [ 62Cu]Cu(PTSM), a positron-emitting radiopharmaceutical for perfusion imaging. The remote system allows the shielded synthesis and purification of tracer using the 2 M HCl eluate of high-level (10–18 GBq) 62Zn/ 62Cu radionuclide generator system. The remote system allows the [ 62Cu]Cu(PTSM) synthesis to be performed in under 8 min with ca 40% E.O.S. radiochemical yield and >98% radiochemical purity.
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ISSN:0883-2889
DOI:10.1016/0883-2889(91)90097-K