N,N-disubstituted 2-aminotetralins are potent D-2 dopamine receptor agonists

Mono- and di-N-substituted 2-amino-5-hydroxytetralins stimulate the D-2 dopamine receptor, 2-(N-n-propyl-N-phenylethylamino)-5-hydroxytetralin being the most potent D-2 agonist encountered to date. In contrast, 2-amino-5-hydroxytetralins only marginally stimulate the D-1 receptor; however, 2-(di-N-n...

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Bibliographic Details
Published inEuropean journal of pharmacology Vol. 105; no. 1-2; p. 15
Main Authors Beaulieu, M, Itoh, Y, Tepper, P, Horn, A S, Kebabian, J W
Format Journal Article
LanguageEnglish
Published Netherlands 01.10.1984
Subjects
Adenylyl Cyclases - metabolism
Animals
Benzamides - pharmacology
Colforsin
Diterpenes - pharmacology
Goldfish
In Vitro Techniques
Naphthalenes - pharmacology
Pituitary Gland, Anterior - metabolism
Prolactin - metabolism
Radioimmunoassay
Rats
Rats, Inbred Strains
Receptors, Dopamine - drug effects
Receptors, Dopamine D2
Retina - enzymology
Tetrahydronaphthalenes - pharmacology
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Summary:Mono- and di-N-substituted 2-amino-5-hydroxytetralins stimulate the D-2 dopamine receptor, 2-(N-n-propyl-N-phenylethylamino)-5-hydroxytetralin being the most potent D-2 agonist encountered to date. In contrast, 2-amino-5-hydroxytetralins only marginally stimulate the D-1 receptor; however, 2-(di-N-n-propylamino)-5, 6-dihydroxytetralin is equipotent with dopamine as a D-1 agonist. The results are discussed within the context of the two dopamine receptor hypothesis.
ISSN:0014-2999
DOI:10.1016/0014-2999(84)90644-7