Chromophobe renal cell carcinoma with sarcomatoid transformation in a dog

A 12-year-old spayed female Siberian husky dog presented with hematuria and weight loss. An abdominal ultrasonographic examination revealed a left renal tumor measuring 8 cm in diameter, and a nephrectomy was performed. The resected kidney contained a cavitated tumor with a white solid region. Histo...

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Bibliographic Details
Published inJournal of veterinary diagnostic investigation Vol. 22; no. 6; p. 983
Main Authors Kobayashi, Naohito, Suzuki, Kazuhiko, Murakami, Hironobu, Kagawa, Eriko, Aoki, Itirou, Nagashima, Yoji
Format Journal Article
LanguageEnglish
Published United States 01.11.2010
Subjects
Animals
Carcinoma, Renal Cell - diagnosis
Carcinoma, Renal Cell - pathology
Carcinoma, Renal Cell - veterinary
Dog Diseases - diagnosis
Dog Diseases - pathology
Dogs
Female
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Summary:A 12-year-old spayed female Siberian husky dog presented with hematuria and weight loss. An abdominal ultrasonographic examination revealed a left renal tumor measuring 8 cm in diameter, and a nephrectomy was performed. The resected kidney contained a cavitated tumor with a white solid region. Histologically, this tumor was composed of large polygonal cells with abundant and cloudy cytoplasm and focal sarcomatoid change. The neoplastic epithelial cells were reactive with colloidal iron staining; Dolichos biflorus agglutinin, peanut agglutinin, and Ulex europaeus agglutinin I lectins; and cluster of differentiation 10 and c-KIT antigens but not for periodic acid-Schiff or vimentin stain. Neoplastic sarcomatoid cells stained positive for vimentin. Because these histopathologic features are identical to those of human chromophobe renal cell carcinoma, the present case was diagnosed as canine chromophobe renal cell carcinoma.
ISSN:1040-6387
DOI:10.1177/104063871002200624