Antibody-mediated functional control of a dansylated polytheonamide mimic

We demonstrate the functional control of a dansylated polytheonamide mimic (2), an artificial ion channel-forming cytotoxic peptide, by the external addition of a polyclonal anti-dansyl antibody (anti-dansyl IgG). The IgG effectively suppressed the ion transport activity and cytotoxicity of 2 in a d...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 50; no. 8; pp. 939 - 941
Main Authors Itoh, Hiroaki, Inoue, Masayuki
Format Journal Article
LanguageEnglish
Published England 01.01.2014
Subjects
Animals
Antibodies
Antibodies - immunology
Biocompatible Materials - chemistry
Biocompatible Materials - metabolism
Biocompatible Materials - pharmacology
Cell Line, Tumor
Cell Survival - drug effects
Ion Transport - drug effects
Mice
Peptides - chemistry
Peptides - metabolism
Phosphatidylcholines - chemistry
Phosphatidylcholines - immunology
Proteins - chemistry
Proteins - metabolism
Proteins - pharmacology
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Summary:We demonstrate the functional control of a dansylated polytheonamide mimic (2), an artificial ion channel-forming cytotoxic peptide, by the external addition of a polyclonal anti-dansyl antibody (anti-dansyl IgG). The IgG effectively suppressed the ion transport activity and cytotoxicity of 2 in a dose-dependent manner.
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ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc48348g