Role of arachidonic acid lipoxygenase pathway in Asthma

• Published in: Prostaglandins & other lipid mediators Vol. 158; p. 106609
• Main Authors: Luo, Yacan, Jin, Minli, Lou, Lejing, Yang, Song, Li, Chengye, Li, Xi, Zhou, Meixi, Cai, Chang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2022
• Subjects: Airway inflammation; Arachidonate 5-Lipoxygenase; Arachidonate Lipoxygenases; Arachidonic acid; Asthma; Asthma - drug therapy; Humans; Leukotrienes; Lipoxins; Lipoxygenase; Lipoxygenases; Airway inflammation; Lipoxygenase; Arachidonic acid; Asthma
• ISSN: 1098-8823
• DOI: 10.1016/j.prostaglandins.2021.106609

•The AA LOXs metabolism pathways play a key role in immunological response and inflammation diseases, such as asthma.•LOXs and their main metabolites in asthma play both anti- and pro-inflammatory role in asthma airway inflammation.•Regulations of LOX expression and activity are associated with the pathogenesis of asthma.•The treatment targe AA LOXs metabolism pathways are application for clinical use. The arachidonic acid (AA) metabolism pathways play a key role in immunological response and inflammation diseases, such as asthma, etc. AA in cell membranes can be metabolized by lipoxygenases (LOXs) to a screen of bioactive substances that include leukotrienes (LTs), lipoxins (LXs), and eicosatetraenoic acids (ETEs), which are considered closely related to the pathophysiology of respiratory allergic disease. Studies also verified that drugs regulating AA LOXs pathway have better rehabilitative intervention for asthma. This review aims to summarize the physiological and pathophysiological importance of AA LOXs metabolism pathways in asthma and to discuss its prospects of therapeutic strategies.