Oxazepam induced mouse killing by rats

Oxazepam (2.5–80 mg/kg) induced significant mouse killing among large samples (N=100/dose) of Holtzman strain albino rats. Meprobamate (2.5–80 mg/kg) and Chlorpromazine (0.5–4 mg/kg) did not induce killing. Despite its lesser tendency to induce aggression in humans, Oxazepam is as potent as Chlordia...

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Bibliographic Details
Published inPharmacology, biochemistry and behavior Vol. 20; no. 2; pp. 311 - 313
Main Authors Leaf, Russell C., Wnek, D.J., Lamon, Stacy
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.02.1984
Elsevier Science
Subjects
Aggression - drug effects
Animals
Biological and medical sciences
Chlordiazepoxide
Chlordiazepoxide - pharmacology
Chlorpromazine
Chlorpromazine - pharmacology
Dose-Response Relationship, Drug
Drug toxicity and drugs side effects treatment
Humans
Male
Medical sciences
Meprobamate
Meprobamate - pharmacology
Mice
Miscellaneous (drug allergy, mutagens, teratogens...)
Mouse killing
Oxazepam
Oxazepam - pharmacology
Pharmacology. Drug treatments
Pilocarpine - pharmacology
Rats
Time Factors
Chlordiazepoxide
Meprobamate
Oxazepam
Mouse killing
Chlorpromazine
Vertebrata
Intraperitoneal administration
Mammalia
Social behavior
Rat
Toxicity
Animal
Rodentia
Agressiveness
Benzodiazepine derivatives
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Summary:Oxazepam (2.5–80 mg/kg) induced significant mouse killing among large samples (N=100/dose) of Holtzman strain albino rats. Meprobamate (2.5–80 mg/kg) and Chlorpromazine (0.5–4 mg/kg) did not induce killing. Despite its lesser tendency to induce aggression in humans, Oxazepam is as potent as Chlordiazepoxide for inducing killing by rats. Induction of mouse killing by rats appears to the predict clinical potency rather than the aggressive side-effects of anxiolytic benzodiazepines.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0091-3057
1873-5177
DOI:10.1016/0091-3057(84)90260-0