The cyanide-metabolizing enzyme rhodanese in rat nasal respiratory and olfactory mucosa

Hydrogen cyanide is a commonly occurring and highly toxic air pollutant. Inhalation of hydrogen cyanide would expose the nasal tissues to its toxic affects unless a detoxicating mechanism were available. Experiments with rat nasal tissues showed that the cyanide-metabolizing enzyme, rhodanese, is pr...

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Bibliographic Details
Published inToxicology letters Vol. 45; no. 2-3; p. 199
Main Author Dahl, A R
Format Journal Article
LanguageEnglish
Published Netherlands 01.02.1989
Subjects
Animals
Cyanides - metabolism
Male
Mitochondria, Liver - enzymology
Nasal Mucosa - enzymology
Olfactory Mucosa - enzymology
Rats
Rats, Inbred F344
Sulfurtransferases - analysis
Thiosulfate Sulfurtransferase - analysis
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Summary:Hydrogen cyanide is a commonly occurring and highly toxic air pollutant. Inhalation of hydrogen cyanide would expose the nasal tissues to its toxic affects unless a detoxicating mechanism were available. Experiments with rat nasal tissues showed that the cyanide-metabolizing enzyme, rhodanese, is present in high concentrations, particularly in the olfactory region. The olfactory tissues had nearly 7-fold more rhodanese on a per mg mitochondrial protein basis than did the liver. These experiments show that nasal metabolism of cyanide may have an important influence on the toxicity of inhaled cyanide and cyanogenic materials.
ISSN:0378-4274
1879-3169
DOI:10.1016/0378-4274(89)90010-6