Antiviral Efficacy of Disinfectant Solution MRI-1

• Published in: Intervirology Vol. 41; no. 6; pp. 238 - 243
• Main Authors: Skinner, G.R.B., Billstrom, M., Randall, S., Buchan, A., Davies, J., Ahmad, A.
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 1998
• Subjects: Animals; Cattle; Detergents - pharmacology; Disinfectants - pharmacology; Ethanol - pharmacology; Guinea Pigs; Herpes simplex virus 1; Herpesvirus 1, Human - drug effects; HIV - drug effects; Human immunodeficiency virus 1; Humans; Influenza A virus; Influenza A virus - drug effects; Original Paper; Polyethylene Glycols - pharmacology; Sodium Dodecyl Sulfate - pharmacology; Surface Properties; Surface-Active Agents - pharmacology; Virus Diseases - virology; Viruses - drug effects; Viruses - growth & development; Disinfectant; Viruses; Herpesvirus
• ISSN: 0300-5526; 1423-0100
• DOI: 10.1159/000024945

Disinfectant MRI-1 was prepared by dissolution of non-ionic and ionic detergent in ethanol. The disinfectant inactivated extracellular and intracellular enveloped and non-enveloped viruses including herpes viruses, influenza A and human immunodeficiency disease virus in suspension or on surfaces by pre-exposure or post-exposure to the disinfectant; in addition, cells were disabled as potential hosts for viral infection using concentrations of MRI-1 which were 50-fold less than the operative concentration for disinfection. There was no evidence of in vitro mutagenicity using Salmonella typhimurium or sensitization or other adverse effect in a guinea pig model or in human subjects.