The Impact of Liver and Renal Dysfunction on the Pharmacokinetics and Pharmacodynamics of Sedative and Analgesic Drugs in Critically Ill Adult Patients

The use of sedative and analgesic drug therapy is often necessary for the care of critically ill patients. Renal and hepatic dysfunction, which occurs frequently in this patient population, can significantly alter drugs' pharmacokinetic and pharmacodynamics properties. By anticipating how these...

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Bibliographic Details
Published inCritical care nursing clinics of North America Vol. 28; no. 2; p. 183
Main Authors Yogaratnam, Dinesh, Ditch, Kristen, Medeiros, Kristin, Miller, Melissa A, Smith, Brian S
Format Journal Article
LanguageEnglish
Published United States 01.06.2016
Subjects
Analgesics - metabolism
Analgesics - pharmacokinetics
Critical Care - methods
Critical Illness
Drug Monitoring - methods
Drug Monitoring - nursing
Humans
Hypnotics and Sedatives - metabolism
Hypnotics and Sedatives - pharmacokinetics
Kidney Diseases - complications
Kidney Diseases - metabolism
Kidney Diseases - physiopathology
Kidney Function Tests
Liver Diseases - complications
Liver Diseases - metabolism
Liver Diseases - physiopathology
Liver Function Tests
Sedatives
Hepatic
Pharmacodynamics
Analgesics
Dysfunction
Renal
Critical care
Pharmacokinetics
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Summary:The use of sedative and analgesic drug therapy is often necessary for the care of critically ill patients. Renal and hepatic dysfunction, which occurs frequently in this patient population, can significantly alter drugs' pharmacokinetic and pharmacodynamics properties. By anticipating how these medications may be affected by liver or kidney dysfunction, health care practitioners may be able to provide tailored dosing regimens that ensure optimal comfort while minimizing the risk of adverse events.
ISSN:1558-3481
DOI:10.1016/j.cnc.2016.02.009