Nitric oxide synthesis inhibitor prevents vasodilation by insulin-like growth factor I

• Published in: Kidney international Vol. 39; no. 2; pp. 333 - 335
• Main Authors: Haylor, John, Singh, Inderjit, Nahas, A. Meguid El
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.1991
• Subjects: Animals; Arginine - analogs & derivatives; Arginine - pharmacology; Indomethacin - pharmacology; Insulin-Like Growth Factor I - antagonists & inhibitors; Insulin-Like Growth Factor I - pharmacology; Kidney - blood supply; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide - antagonists & inhibitors; Nitric Oxide - chemistry; Nitric Oxide - physiology; Rats; Rats, Inbred Strains; Renal Circulation - drug effects; Vasodilation - drug effects
• ISSN: 0085-2538; 1523-1755
• DOI: 10.1038/ki.1991.42

Nitric oxide synthesis inhibitor prevents vasodilation by insulin-like growth factor I. The effect of insulin-like growth factor I (IGF-I) on renal blood flow was measured in the anaesthetized rat using an electromagnetic flow probe. Renal vasodilation induced by IGF-I (50 µg/kg) was completely inhibited by NG-nitro-l-arginine methyl ester (50 mg/kg), an inhibitor of nitric oxide biosynthesis, but only partially reduced by indomethacin (10 mg/kg). The involvement of nitric oxide synthesis in the renal actions of IGF-I is proposed.