Cytogenetic effects of epoxy resin in man: dependence on sex, age and period of exposure

The cytogenetic analysis of 156 subjects occupationally exposed to epoxy resin has revealed sex-dependent differences: average frequencies of aberrant metaphases and chromosome breaks per cell were significantly higher in males than in females. No linear or other functional relationship between the...

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Bibliographic Details
Published inMutation Research/Genetic Toxicology Vol. 155; no. 3; pp. 127 - 129
Main Authors Sazonova, L.A., Suskov, I.I.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.03.1985
Subjects
Adult
Age Factors
Chromosome Aberrations
Chromosomes, Human - drug effects
Environmental Exposure
Epoxy Resins - pharmacology
Female
Humans
Lymphocytes - ultrastructure
Male
Middle Aged
Occupations
Sex Factors
Time Factors
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Summary:The cytogenetic analysis of 156 subjects occupationally exposed to epoxy resin has revealed sex-dependent differences: average frequencies of aberrant metaphases and chromosome breaks per cell were significantly higher in males than in females. No linear or other functional relationship between the frequency of aberrant metaphases and the period of exposure to the resin has been revealed. However, a significantly higher average frequency of aberrant metaphases was observed in the group of elderly workers with a long period of exposure. The distribution of individuals according to the frequency of aberrant metaphases in the control group does not differ significantly from Poisson's law, while in individuals exposed to epoxy resin it is closer to the normal distribution.
ISSN:0165-1218
0027-5107
DOI:10.1016/0165-1218(85)90130-2