Organic anion transport study in mutant rats with autosomal recessive conjugated hyperbilirubinemia

The EHBR is a mutant rat strain with congenital conjugated hyperbilirubinemia bred from a Sprague-Dawley rat. Transport of conjugated bilirubin, indocyanine green, and tetrabromosulfophtalein from liver to bile is severely impaired in these rats. Serum bilirubin amounts to 6.0 +/- 0.05 mg/dl (n = 4)...

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Published inLife sciences (1973) Vol. 49; no. 14; p. 1003
Main Authors Kurisu, H, Kamisaka, K, Koyo, T, Yamasuge, S, Igarashi, H, Maezawa, H, Uesugi, T, Tagaya, O
Format Journal Article
LanguageEnglish
Published Netherlands 1991
Subjects
Animals
Bile - chemistry
Bile Acids and Salts - analysis
Bilirubin - analogs & derivatives
Bilirubin - blood
Bilirubin - metabolism
Bilirubin - pharmacokinetics
Hyperbilirubinemia, Hereditary - metabolism
Indocyanine Green - pharmacokinetics
Rats
Rats, Inbred SHR
Rats, Inbred Strains
Rats, Mutant Strains
Sulfobromophthalein - pharmacokinetics
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Summary:The EHBR is a mutant rat strain with congenital conjugated hyperbilirubinemia bred from a Sprague-Dawley rat. Transport of conjugated bilirubin, indocyanine green, and tetrabromosulfophtalein from liver to bile is severely impaired in these rats. Serum bilirubin amounts to 6.0 +/- 0.05 mg/dl (n = 4) in adult rats, with 97% conjugates. The bile flow is reduced to about 65% of the control group, whereas total bile acid in 10-min bile samples is similar. Liver histology of 10 week-old rats revealed neither intracellular pigmentation nor architectural abnormalities.
ISSN:0024-3205
DOI:10.1016/0024-3205(91)90301-Q