Delayed progression of cytotoxic oedema in focal cerebral ischemia after treatment with a torasemide derivative: a diffusion-weighted magnetic resonance imaging study

• Published in: Neuroscience letters Vol. 213; no. 2; pp. 123 - 126
• Main Authors: Bars, Emmanuelle Le, Roussel, Simon, Rémy, Chantal, Loubinoux, Isabelle, Devoulon, Philippe, Méric, Philippe, Pinard, Elisabeth, Dupeyre, Roger, Décorps, Michel, Massarelli, Raphaël
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 02.08.1996; Elsevier
• Subjects: Animals; Antihypertensive Agents - pharmacology; Biological and medical sciences; Brain ischemia; Brain Ischemia - diagnosis; Brain Ischemia - drug therapy; Brain Ischemia - physiopathology; Cytotoxic oedema; Diffusion magnetic resonance imaging; Disease Progression; Edema - diagnosis; Edema - drug therapy; Edema - physiopathology; Magnetic Resonance Imaging; Male; Medical sciences; Middle cerebral artery occlusion; Na +2Cl −K + cotransporter; Neurology; Rats; Rats, Sprague-Dawley; Sulfonamides - pharmacology; Time Factors; Torasemide; Torsemide; Vascular diseases and vascular malformations of the nervous system; Brain ischemia; Cytotoxic oedema; Diffusion magnetic resonance imaging; Middle cerebral artery occlusion; Torasemide; Na +2Cl −K + cotransporter; Nervous system diseases; Rat; Rodentia; Ion transport; Cardiovascular disease; Cytotoxicity; Nuclear magnetic resonance imaging; Cerebral disorder; Vascular disease; Vertebrata; Experimental disease; Mammalia; Ischemia; Animal; Imaging; Central nervous system disease; Inhibitor; Cerebrovascular disease; Brain (vertebrata)
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/0304-3940(96)12869-X

Diffusion-weighted magnetic resonance imaging (MRI) was used to assess the effect of an astrocytic Na +2Cl −1K + cotransporter inhibitor, a novel torasemide derivative, on the time course and spatial evolution of a focal cerebral ischemia in the rat. The drug (1 mg/ kg, i.p.) was injected 30 min before middle cerebral artery occlusion and diffusion-weighted images were acquired at various times thereafter. The results showed that the drug reduced the size of the hyperintensity during the first hours, but did not affect the time constant of growth or the final size. The temporary reduction of the cytotoxic oedema induced by the torasemide derivative, demonstrates an antioedematous activity.