Inhibition of HSV-1 and vaccinia virus replication by cephalosporin derivatives

Derivatives of beta-lactam antibiotics of the cephalosporin type at 0.02-1 mM concentrations interfered with in vitro replication of two DNA-containing viruses, herpes simplex I and vaccinia, but showed no effects on two RNA-viruses, lymphocytic choriomeningitis virus and vesicular stomatitis virus,...

Full description

Saved in:
Bibliographic Details
Published inAntiviral research Vol. 10; no. 1-3; p. 59
Main Authors Cottagnoud, P, Neftel, K A, Hany, M, Zinkernagel, R M
Format Journal Article
LanguageEnglish
Published Netherlands 01.11.1988
Subjects
Animals
Cephalosporins - metabolism
Cephalosporins - pharmacology
Cercopithecus aethiops
Chemical Phenomena
Chemistry
Penicillin G - pharmacology
Simplexvirus - drug effects
Simplexvirus - physiology
Structure-Activity Relationship
Vaccinia virus - drug effects
Vaccinia virus - physiology
Vero Cells
Virus Replication - drug effects
Online AccessGet more information

Cover

More Information
Summary:Derivatives of beta-lactam antibiotics of the cephalosporin type at 0.02-1 mM concentrations interfered with in vitro replication of two DNA-containing viruses, herpes simplex I and vaccinia, but showed no effects on two RNA-viruses, lymphocytic choriomeningitis virus and vesicular stomatitis virus, or on cell viability. The exact structure of the active compounds remains unknown, but opening of the beta-lactam ring appears to be a prerequisite for their formation. Whereas cephalosporin derivatives were most active, no active products were obtained from penicillins and monobactams. The potential of these unexpected antiviral effects of widely used beta-lactam antibiotics remains subject of further study.
ISSN:0166-3542
DOI:10.1016/0166-3542(88)90014-9