Release of atrial natriuretic polypeptide by graded right atrial distension in anesthetized dogs

• Published in: Life sciences (1973) Vol. 40; no. 2; p. 119
• Main Authors: Akabane, S, Kojima, S, Igarashi, Y, Kawamura, M, Matsushima, Y, Ito, K
• Format: Journal Article
• Language: English
• Published: Netherlands 12.01.1987
• Subjects: Animals; Atrial Function; Atrial Natriuretic Factor - blood; Atrial Natriuretic Factor - metabolism; Atrial Natriuretic Factor - physiology; Blood Pressure; Dogs; Female; Heart Atria - metabolism; Heart Rate; Male
• ISSN: 0024-3205
• DOI: 10.1016/0024-3205(87)90350-X

In order to verify the contribution of right atrial pressure to atrial natriuretic polypeptides (ANP) release, we measured plasma levels of immunoreactive (ir)-ANP when graded rise of right atrial pressure was executed in anesthetized dogs. Increasing right atrial pressure (RAP) from 2.7 +/- 0.6 to 9.0 +/- 0.7 mmHg, plasma levels of ir-ANP in aorta tended to increase by 33% but not significantly (p greater than 0.05). However, when RAP was increased from 9.0 +/- 0.7 to 17.0 +/- 1.1 mmHg, ir-ANP levels in aorta were significantly (p less than 0.05) increased by 132% of control within 5 min from the start of RAP elevation. The RAP elevation produced a sustained increase in plasma levels of ir-ANP. There was a positive correlation between right atrial pressure and plasma levels of ir-ANP. The plasma levels of ir-ANP were similar between aorta and pulmonary artery. These results demonstrate that increasing atrial pressure is closely correlated with ANP release and ANP is not greatly metabolized by pulmonary circulation.