Alteration of synergistic immune response in gut–liver axis of white crucian carp (Carassius cuvieri) after gut infection with Aeromonas hydrophila

• Published in: Journal of fish diseases Vol. 46; no. 9; pp. 917 - 927
• Main Authors: Wang, Fei, Qin, Zi‐Le, Luo, Wei‐Sheng, Xiong, Ning‐Xia, Huang, Ming‐Zhu, Ou, Jie, Luo, Sheng‐Wei, Liu, Shao‐Jun
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.09.2023
• Subjects: Aeromonas hydrophila; Antioxidant properties; antioxidant status; antioxidants; Aquaculture; Carassius cuvieri; Carp; crucian carp; Defence mechanisms; Deformation; farmed fish; Fish; Gene expression; gene expressions; genes; Goblet cells; gut infection; Immune response; Immune system; Immunity; Immunomodulation; Liver; Midgut; Survival; tight junctions; gut infection; gene expressions; crucian carp; antioxidant status
• ISSN: 0140-7775; 1365-2761; 1365-2761
• DOI: 10.1111/jfd.13799

Aeromonas hydrophila can pose a great threat to the survival of farmed fish. In current study, we investigated the pathological characteristics and immune response in gut–liver axis of white crucian carp (WCC) upon gut infection. WCC anally intubated with A. hydrophila exerted a tissue deformation in damaged midgut with elevated levels of goblet cells along with a significant decrease in tight junction proteins and villi length‐to‐width ratios. In addition, immune‐related gene expressions and antioxidant properties increased dramatically in gut–liver axis of WCC following gut infection with A. hydrophila. These results highlighted the immune modulation and redox alteration in gut–liver axis of WCC in response to gut infection.