Effects of dihydromyricetin on ARPE‐19 cell migration through regulating matrix metalloproteinase‐2 expression

• Published in: Environmental toxicology Vol. 33; no. 12; pp. 1298 - 1303
• Main Authors: Wang, Kai, Yang, Shun‐Fa, Hsieh, Yi‐Hsien, Chang, Yuan‐Yen, Yu, Nuo‐Yi, Lin, Hui‐Wen, Lin, Hung‐Yu
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.12.2018; Wiley Subscription Services, Inc
• Subjects: adjuvants; Ampelopsis grossedentata; bioactive properties; Cell adhesion & migration; Cell migration; cell movement; Cell Movement - drug effects; Cells; Cells, Cultured; dihydromyricetin (DHM); Epithelial Cells - drug effects; Epithelial Cells - physiology; epithelium; Extracellular; Flavonols - pharmacology; gelatinase A; Humans; JNK protein; Kinases; Matrix metalloproteinase; Matrix Metalloproteinase 2 - metabolism; Metalloproteinase; Metastases; migration; mitogen-activated protein kinase; Mitogen-Activated Protein Kinase 3 - metabolism; Mitogen-Activated Protein Kinases - metabolism; MMP‐2; Phosphorylation; proliferative vitreoretinopathy; Proteins; Retina; Retina - cytology; Retina - drug effects; Retina - metabolism; therapeutics; Vitreoretinopathy, Proliferative - metabolism; Vitreoretinopathy, Proliferative - pathology; Western blotting; migration; MMP-2; dihydromyricetin (DHM); proliferative vitreoretinopathy

Dihydromyricetin (DHM), a flavanonol compound in Ampelopsis grossedentata, possesses several biological activities. However, the molecular mechanism underlying the effects of DHM on human proliferative vitreoretinopathy (PVR) remains unclear. We explored the effects of DHM on cell migration and the...