Thorough characterization and stability of HP‐β‐cyclodextrin thymol inclusion complexes prepared by microwave technology: A required approach to a successful application in food industry

BACKGROUND The aims of the present study were to obtain a stable dry powder formulation of cyclodextrins (CDs) encapsulating thymol, for successful use as an ingredient on an industrial scale, and to characterize the thymol‐CDs complexes using different techniques. RESULTS Thymol was successfully so...

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Published inJournal of the science of food and agriculture Vol. 99; no. 3; pp. 1322 - 1333
Main Authors Rodríguez‐López, María Isabel, Mercader‐Ros, María Teresa, López‐Miranda, Santiago, Pellicer, José A, Pérez‐Garrido, Alfonso, Pérez‐Sánchez, Horacio, Núñez‐Delicado, Estrella, Gabaldón, José A
Format Journal Article
LanguageEnglish
Published Chichester, UK John Wiley & Sons, Ltd 01.02.2019
John Wiley and Sons, Limited
Subjects
Aqueous solutions
Cyclodextrin
Cyclodextrins
Encapsulation
Food industry
Food processing industry
HP‐β‐CDs
Inclusion complexes
Industrial applications
ingredients
microwave irradiation
Organic chemistry
pH effects
Powder
solubilization
spray‐drying
Thymol
encapsulation
thymol
microwave irradiation
HP-β-CDs
spray-drying
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Summary:BACKGROUND The aims of the present study were to obtain a stable dry powder formulation of cyclodextrins (CDs) encapsulating thymol, for successful use as an ingredient on an industrial scale, and to characterize the thymol‐CDs complexes using different techniques. RESULTS Thymol was successfully solubilized in aqueous solutions and the Kc value increased with the pH of the media until the pH was neutral, giving the highest values (2583 ± 176 L mol−1) for HP‐β‐cyclodextrins (HP‐β‐CDs). The best encapsulation efficiency of thymol in solid complexes was obtained using the microwave (MWI) encapsulation method. The different characterization techniques have demonstrated the affinity of HP‐β‐CDs for thymol molecules, forming stable complexes. CONCLUSIONS The results support the use of the MWI method in the preparation of solid HP‐β‐CD‐thymol complexes, due to greater encapsulation efficiency and technological and economic advantages for industrial applications. © 2018 Society of Chemical Industry
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ISSN:0022-5142
1097-0010
1097-0010
DOI:10.1002/jsfa.9307