Retrospective analysis of factors influencing oncologic outcome in 590 patients with early‐intermediate glottic cancer treated by transoral laser microsurgery

• Published in: Head & neck Vol. 39; no. 1; pp. 71 - 81
• Main Authors: Ansarin, Mohssen, Cattaneo, Augusto, De Benedetto, Luigi, Zorzi, Stefano, Lombardi, Francesca, Alterio, Daniela, Rocca, Maria Cossu, Scelsi, Daniele, Preda, Lorenzo, Chiesa, Fausto, Santoro, Luigi
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.01.2017
• Subjects: Adult; Aged; Aged, 80 and over; Cancer; Carcinoma - mortality; Carcinoma - pathology; Carcinoma - surgery; Combined Modality Therapy; Disease-Free Survival; Female; Glottis; Humans; laryngeal cancer; Laryngeal Neoplasms - mortality; Laryngeal Neoplasms - pathology; Laryngeal Neoplasms - surgery; Laser Therapy; Male; Microsurgery; Middle Aged; Neoplasm Staging; organ preservation; overall survival; relapse‐free survival; Retrospective Studies; Survival Rate; transoral laryngeal microsurgery; Treatment Outcome; relapse-free survival; overall survival; laryngeal cancer; transoral laryngeal microsurgery; organ preservation
• ISSN: 1043-3074; 1097-0347
• DOI: 10.1002/hed.24534

Background The purpose of this study was to identify the factors influencing oncologic outcomes for patients with early‐intermediate glottic cancer treated by transoral laser microsurgery (TLM). Methods This was a retrospective mono‐institutional study. A total of 590 patients with cTis‐cT3 glottic cancer underwent TLM with curative intent. Results TLM alone was performed in 538 patients (91.2%) and TLM followed by adjuvant radiotherapy (RT) was done in 52 (8.8%). Five‐year recurrence‐free survival (RFS) and 10‐year overall survival (OS) were 85.3% and 74.7%, respectively. The larynx‐preservation ratio was 95.9%. In particular, from our data, we found that occult metastases were rare (1.2%); preventive tracheotomy was not necessary; the local recurrence rate of Tis was similar to that in the T2 and T3 group; and no major or lethal complications were observed. Conclusion Age (>60 vs ≤60), type of cordectomy (≥IV vs ≤III), status of margins, fixed arytenoid, and pathologic T classification, were the variables associated with RFS, OS, and organ‐preservation rate. © 2016 Wiley Periodicals, Head Neck 39: 71–81, 2017