Merkel cell carcinoma on the dorsalis pedis with both dot‐like perinuclear and cytoplasmic patterns of CK20 positivity

Classically known to be a tumor of the head and neck region, primary Merkel cell carcinoma (MCC) has rarely been reported in the lower leg. The present case showed both dot‐like perinuclear and cytoplasmic patterns of CK20 positivity in the primary MCC. We propose that the presence of both dot‐like...

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Bibliographic Details
Published inJournal of cutaneous immunology and allergy Vol. 5; no. 5; pp. 194 - 195
Main Authors Yokoyama, Kae, Ikeda, Takaharu, Kawakami, Tamihiro
Format Journal Article
LanguageEnglish
Published Tokyo Frontiers Media SA 01.10.2022
Frontiers Media S.A
Subjects
Asymptomatic
Biopsy
Cancer
Conflicts of interest
Cytoplasm
Lymphatic system
Skin
Skin cancer
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Summary:Classically known to be a tumor of the head and neck region, primary Merkel cell carcinoma (MCC) has rarely been reported in the lower leg. The present case showed both dot‐like perinuclear and cytoplasmic patterns of CK20 positivity in the primary MCC. We propose that the presence of both dot‐like perinuclear and cytoplasmic patterns of CK20 could reflect the diversity of MCC origin from stem cell to mature Merkel cells in our patient.
ISSN:2574-4593
2574-4593
DOI:10.1002/cia2.12243