Drug-Induced Sleep Endoscopy in Pediatric Obstructive Sleep Apnea

• Published in: Otolaryngology-head and neck surgery Vol. 164; no. 2; p. 414
• Main Authors: Raposo, Diogo, Menezes, Marco, Rito, João, Trindade-Soares, Mafalda, Adónis, Cristina, Loureiro, Helena Cristina, Freire, Filipe
• Format: Journal Article
• Language: English
• Published: England 01.02.2021
• Subjects: Adenoidectomy - methods; Airway Obstruction - complications; Airway Obstruction - surgery; Child; Endoscopy - methods; Female; Follow-Up Studies; Humans; Hypnotics and Sedatives - administration & dosage; Infusions, Intravenous; Male; Polysomnography; Propofol - administration & dosage; Retrospective Studies; Sleep - drug effects; Sleep Apnea, Obstructive - diagnosis; Sleep Apnea, Obstructive - etiology; Sleep Apnea, Obstructive - physiopathology; Tonsillectomy - methods; drug-induced sleep apnea; obstructive sleep apnea; persistent; naïve; DISE; pediatric
• ISSN: 1097-6817
• DOI: 10.1177/0194599820947666

To describe drug-induced sleep endoscopy (DISE) findings in children with obstructive sleep apnea and to differentiate them between surgically naïve children and children who had adenotonsillectomy performed. Retrospective case series with chart review. Secondary care hospital. A cohort of 56 children with the diagnosis of obstructive sleep apnea was submitted to DISE and subsequent upper airway surgery: 23 were surgically naïve, and 33 had persistent obstructive sleep apnea after adenotonsillectomy. Comparisons between groups were calculated with chi-square test and Student's test. Simple linear regression was used to model polysomnographic indices. In surgically naïve children, the most common sites of obstruction were the adenoids (78.2%) and the lateral pharyngeal walls/tonsils (82.6%). In children with persistent obstructive sleep apnea after adenotonsillectomy, the most common sites of obstruction were the adenoids (54.5%), followed by the supraglottis (48.5%) and the tongue base (45.5%). No correlation was found between obstructive apnea-hypopnea index and DISE findings. Simple linear regression revealed that the degree of obstruction at the tongue base (β = -0.73; 95% CI, -1.22 to -0.25; = .004) and the presence of multilevel obstruction (β = -1.75; 95% CI, -3.20 to -0.30; = .02) predicted saturation nadir in children with persistent obstructive sleep apnea after adenotonsillectomy. DISE findings differed between surgically naïve children and children with persistent obstructive sleep apnea after adenotonsillectomy. Increased obstruction at the level of the tongue base and the presence of multilevel obstruction predicted a lower saturation nadir in children with persistent obstructive sleep apnea after adenotonsillectomy.