Transmission/disequilibrium tests of androgen receptor and glutathione S‐transferase pi variants in prostate cancer families

• Published in: International journal of cancer Vol. 98; no. 6; pp. 938 - 942
• Main Authors: Ho, Gloria Y.F., Knapp, Michael, Freije, Diha, Nelson, William G., Smith, Jeffrey R., Carpten, John D., Bailey‐Wilson, Joan E., Beaty, Terri H., Petersen, Gloria, Xu, Jianfeng, Kamensky, Victor, Walsh, Patrick C., Isaacs, William B.
• Format: Journal Article
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 20.04.2002; Wiley-Liss
• Subjects: Adult; Aged; Aged, 80 and over; androgen receptor; Biological and medical sciences; Case-Control Studies; Disease Transmission, Infectious; DNA Primers - chemistry; DNA, Neoplasm - blood; DNA, Neoplasm - genetics; Glutathione S-Transferase pi; Glutathione Transferase - genetics; Humans; Isoenzymes - genetics; Linkage Disequilibrium - genetics; Male; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Polymerase Chain Reaction; Polymorphism, Genetic; prostate cancer; Prostatic Neoplasms - genetics; Receptors, Androgen - genetics; Repetitive Sequences, Nucleic Acid; Risk Factors; transmission disequilibrium test; Tumors of the urinary system; Urinary tract. Prostate gland; X Chromosome - genetics; North America; America; Human; Urinary system disease; Genetic variability; Prostate disease; Androgen; Enzyme; Isozyme; Transferases; Genotype; Malignant tumor; Epidemiology; Aggregation; Gene; Glutathione transferase; Risk factor; Genetics; Familial cancer; Sex steroid hormone; Male genital diseases; Prostate; Public health; Polymorphism; Biological receptor; Hormonal receptor
• ISSN: 0020-7136; 1097-0215
• DOI: 10.1002/ijc.10290

Population‐based case‐control studies have found relationships between risk of prostate cancer and genetic polymorphisms in the CAG repeat and GGC repeat of the X‐linked androgen receptor gene (AR) as well as the autosomal gene coding for glutathione S‐transferase pi (GSTP1). This family‐based study utilized the transmission disequilibrium test to examine whether there was evidence that these polymorphisms could account for familial aggregation of prostate cancer. Seventy‐nine North American pedigrees were studied. Most of these families had 3 or more affected first‐degree relatives. Genotype information was obtained on 578 individuals. The reconstruction combined transmission disequilibrium test (RC‐TDT) was used to test for linkage. There was no evidence of linkage to the CAG and GGC repeat sequences in the AR gene or the pentanucleotide (ATAAA) repeat in the GSTP1 gene when each allele was analyzed separately or when alleles were grouped by repeat length. Our findings do not support the hypothesis that familial clustering of prostate cancer in high‐risk families is attributable to these genetic variants. © 2002 Wiley‐Liss, Inc.