Oxidative damage of the male reproductive system induced by paraquat

• Published in: Journal of biochemical and molecular toxicology Vol. 31; no. 3
• Main Authors: Chen, Qing, Zhang, Xin, Zhao, Jin‐Yan, Lu, Xiao‐Ning, Zheng, Peng‐Sheng, Xue, Xiang
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.03.2017
• Subjects: Animals; Apoptosis; Apoptosis - drug effects; Cell Survival - drug effects; Herbicides - toxicity; Lipid Peroxidation - drug effects; Male; Mitochondria - drug effects; Mitochondria - pathology; mitochondrial pathway; oxidative damage; Oxidative Stress - drug effects; Paraquat; Paraquat - toxicity; Rats; Reproductive system; Rodents; Sperm Count; Sperm Motility - drug effects; Teratozoospermia - chemically induced; Teratozoospermia - physiopathology; mitochondrial pathway; Paraquat; oxidative damage; reproductive system
• ISSN: 1095-6670; 1099-0461
• DOI: 10.1002/jbt.21870

The effects of paraquat (PQ) on the male reproductive system are unclear. In this study, male rats were divided into four groups (0, 0.5, 2, and 8 mg/kg) and treated with PQ by oral gavage for 8 weeks. At the end of the experiment, a significant decline in sperm count, motility, and viability and an increase in teratospermia were observed in the PQ‐treated group (P < 0.05). Further investigation found that PQ resulted in enhanced lipid peroxidation and more apoptosis in the testis tissues, and apoptosis was likely to be associated with activation of the mitochondrial pathway. In summary, our study demonstrated oxidative damage due to PQ on the male reproductive system.