The role of lncRNA-mediated ceRNA regulatory networks in pancreatic cancer

Non-coding RNAs (ncRNAs), which occupy the vast majority of human transcripts are known for their inability to encode proteins. NcRNAs consist of a diverse range of RNA species, including long non-coding RNAs (lncRNAs), which have significant meaning for epigenetic modification, post-transcriptional...

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Published inCell death discovery Vol. 8; no. 1; p. 287
Main Authors Xu, Jichuan, Xu, Jian, Liu, Xinyuan, Jiang, Jianxin
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 14.06.2022
Springer Nature B.V
Nature Publishing Group
Subjects
631/67/1059/602
692/699/67/1059/602
Apoptosis
Biochemistry
Biomarkers
Biomedical and Life Sciences
Cell Biology
Cell Cycle Analysis
Diagnosis
Epigenetics
Gene regulation
Life Sciences
Medical prognosis
MicroRNAs
miRNA
Non-coding RNA
Pancreatic cancer
Pancreatic carcinoma
Post-transcription
Prognosis
Regulatory sequences
Review
Review Article
Stem Cells
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Summary:Non-coding RNAs (ncRNAs), which occupy the vast majority of human transcripts are known for their inability to encode proteins. NcRNAs consist of a diverse range of RNA species, including long non-coding RNAs (lncRNAs), which have significant meaning for epigenetic modification, post-transcriptional regulation of target genes, molecular interference, etc. The dysregulation of ncRNAs will mediate the pathogenesis of diverse human diseases, like cancer. Pancreatic cancer, as one of the most lethal malignancies in the digestive system that is hard to make a definite diagnosis at an early clinicopathological stage with a miserable prognosis. Therefore, the identification of potential and clinically applicable biomarker is momentous to improve the overall survival rate and positively ameliorate the prognosis of patients with pancreatic carcinoma. LncRNAs as one kind of ncRNAs exert multitudinous biological functions, and act as molecular sponges, relying on microRNA response elements (MREs) to competitively target microRNAs (miRNAs), thereby attenuating the degradation or inhibition of miRNAs to their own downstream protein-coding target genes, also thus regulating the initiation and progression of neoplasms. LncRNAs, which emerge aforementioned function are called competing endogenous RNAs (ceRNAs). Consequently, abundant research of lncRNAs as potential biomarkers is of critical significance for the molecular diagnosis, targeted therapy, as well as prognosis monitoring of pancreatic cancer.
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ISSN:2058-7716
2058-7716
DOI:10.1038/s41420-022-01061-x