Stalled but not forgotten: Bacterial exotoxins inhibit translation to activate NLRP1

In this issue of JEM, companion articles from Pinilla et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20230104) and Robinson et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20230105) demonstrate that ribotoxic stress induced by Pseudomonas aeruginosa and Corynebacterium diphtheriae EEF2-...

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Published inThe Journal of experimental medicine Vol. 220; no. 10
Main Authors Tibble, Ryan, Yonemitsu, Marisa A, Mitchell, Patrick S
Format Journal Article
LanguageEnglish
Published United States Rockefeller University Press 02.10.2023
Subjects
Exotoxins
Humans
Infectious Disease and Host Defense
Inflammasomes
Innate Immunity and Inflammation
Innate Immunity Recognition
Insights
Memory Disorders
NLR Proteins
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Summary:In this issue of JEM, companion articles from Pinilla et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20230104) and Robinson et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20230105) demonstrate that ribotoxic stress induced by Pseudomonas aeruginosa and Corynebacterium diphtheriae EEF2-targeting exotoxins leads to NLRP1 inflammasome activation, representing a new mechanism of effector-triggered immunity.
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Disclosures: The authors declare no competing financial interests.
R. Tibble and M.A. Yonemitsu contributed equally to this paper.
ISSN:0022-1007
1540-9538
DOI:10.1084/jem.20231160