Non-epidermidis coagulase-negative staphylococcal bacteremia: clinical predictors of true bacteremia

• Published in: European journal of clinical microbiology & infectious diseases Vol. 23; no. 6; pp. 495 - 498
• Main Authors: RUHE, J, MENON, A, MUSHATT, D, DEJACE, P, HASBUN, R
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.06.2004; Springer Nature B.V
• Subjects: Adult; Age Distribution; Aged; Aged, 80 and over; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Antibiotic resistance; Bacteremia - diagnosis; Bacteremia - drug therapy; Bacteremia - epidemiology; Bacteria; Bacterial diseases; Biological and medical sciences; Blood; Catheters; Coagulase - metabolism; Cohort Studies; Confidence Intervals; Drug Resistance, Bacterial; Female; Fundamental and applied biological sciences. Psychology; Human bacterial diseases; Humans; Incidence; Infectious diseases; Logistic Models; Male; Medical instruments; Medical sciences; Microbial Sensitivity Tests; Microbiology; Middle Aged; Multivariate analysis; Predictive Value of Tests; Probability; Prognosis; Retrospective Studies; Risk Assessment; Risk factors; Severity of Illness Index; Staphylococcal Infections - diagnosis; Staphylococcal Infections - drug therapy; Staphylococcal Infections - epidemiology; Staphylococcal infections, streptococcal infections, pneumococcal infections; Staphylococcus - classification; Staphylococcus - enzymology; Staphylococcus epidermidis; Infection; Bacteriosis; Microbiology; Predictive factor; Staphylococcal infection; Bacteremia
• ISSN: 0934-9723; 1435-4373
• DOI: 10.1007/s10096-004-1134-4

In order to explore the clinical significance and risk factors for true bacteremia caused by coagulase-negative staphylococci (CNS) other than Staphylococcus epidermidis, a retrospective cohort study of 160 patients with at least one blood culture positive for non- epidermidis CNS was performed. True bacteremia was diagnosed in 32 (20%) of the patients. On multivariate analysis the following factors were associated with true bacteremia: (i) more than one positive blood culture, (ii) presence of a central venous catheter, and (iii) methicillin resistance. The results of this study indicate that non- epidermidis CNS can cause significant bloodstream infections.