Serum levels of soluble adhesion molecules ICAM-1, VCAM-1 and E-selectin in patients with Wegener's granulomatosis

• Published in: Auris, nasus, larynx Vol. 28; no. 4; pp. 311 - 314
• Main Authors: Ohta, Nobuo, Fukase, Shigeru, Aoyagi, Masaru
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ireland Ltd 01.11.2001
• Subjects: Adult; Aged; E-selectin; E-Selectin - blood; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Granulomatosis with Polyangiitis - diagnosis; Granulomatosis with Polyangiitis - immunology; Humans; ICAM-1; Intercellular Adhesion Molecule-1 - blood; Interleukin-6 - blood; Male; Middle Aged; Reference Values; Tumor Necrosis Factor-alpha - metabolism; Vascular Cell Adhesion Molecule-1 - blood; VCAM-1; Wegener's granulomatosis; E-selectin; VCAM-1; ICAM-1; Wegener's granulomatosis
• ISSN: 0385-8146; 1879-1476
• DOI: 10.1016/S0385-8146(01)00097-9

Objective: To examine the role of soluble intercellular adhesion molecule 1 (sICAM-1), soluble vascular cell adhesion molecule 1 (sVCAM-1), and soluble E-selectin (sE-selectin) in the pathogenesis of Wegener's granulomatosis (WG) and the values of measuring serum levels of these soluble adhesion molecules for monitoring disease activity during follow-up, a total of 24 serum samples from 16 patients with WG were studied. Methods: The serum concentrations of soluble adhesion molecules (sICAM-1, sVCAM-1 and sE-selectin) and cytokines (tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6)) of patients with WG were measured by ELISA. Results: The serum levels of sICAM-1 were significantly elevated in active WG and correlated with disease activity. At the time of relapse, a significant increase of sICAM-1 was also observed. The serum levels of TNF-α and IL-6 were also significantly elevated in active WG. Conclusion: These findings suggest that sICAM-1 plays an important role in the pathogenesis of WG and may be used as an additional parameter of disease activity.