Embracing the heterogeneity of natural viruses in mouse studies

Animal models are a critical tool in modern biology. To increase reproducibility and to reduce confounding variables modern animal models exclude many microbes, including key natural commensals and pathogens. Here we discuss recent strategies to incorporate a natural microbiota to laboratory mouse m...

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Bibliographic Details
Published inJournal of general virology Vol. 103; no. 6
Main Authors Fiege, Jessica K, Langlois, Ryan A
Format Journal Article
LanguageEnglish
Published England Microbiology Society 01.06.2022
Subjects
Animals
Disease Models, Animal
Mice
Microbiota
Reproducibility of Results
Reviews
Symbiosis
Viruses - genetics
virome
microbiome
dirty mice
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Summary:Animal models are a critical tool in modern biology. To increase reproducibility and to reduce confounding variables modern animal models exclude many microbes, including key natural commensals and pathogens. Here we discuss recent strategies to incorporate a natural microbiota to laboratory mouse models and the impacts the microbiota has on immune responses, with a focus on viruses.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0022-1317
1465-2099
DOI:10.1099/jgv.0.001758