Embracing the heterogeneity of natural viruses in mouse studies
Animal models are a critical tool in modern biology. To increase reproducibility and to reduce confounding variables modern animal models exclude many microbes, including key natural commensals and pathogens. Here we discuss recent strategies to incorporate a natural microbiota to laboratory mouse m...
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Published in | Journal of general virology Vol. 103; no. 6 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
Microbiology Society
01.06.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Animal models are a critical tool in modern biology. To increase reproducibility and to reduce confounding variables modern animal models exclude many microbes, including key natural commensals and pathogens. Here we discuss recent strategies to incorporate a natural microbiota to laboratory mouse models and the impacts the microbiota has on immune responses, with a focus on viruses. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0022-1317 1465-2099 |
DOI: | 10.1099/jgv.0.001758 |