Time- and Spectrally-Resolved Photoluminescence Study of Alloyed CdxZn1−xSeyS1−y/ZnS Quantum Dots and Their Nanocomposites with SPIONs in Living Cells

Magnetic-luminescent composites based on semiconductor quantum dots (QDs) and superparamagnetic iron oxide nanoparticles (SPIONs) can serve as a platform combining visualization and therapy. Here, we report the construction of QD-SPION nanocomposites based on synthesized SPIONs and alloyed QDs (CdxZ...

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Published inInternational journal of molecular sciences Vol. 23; no. 7; p. 4061
Main Authors Matiushkina, Anna, Litvinov, Ilia, Bazhenova, Anastasia, Belyaeva, Tatiana, Dubavik, Aliaksei, Veniaminov, Andrei, Maslov, Vladimir, Kornilova, Elena, Orlova, Anna
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 06.04.2022
MDPI
Subjects
Alloying
Cell surface
Decay
Endosomes
Fever
Hyperthermia
Iron oxides
Laboratory animals
Localization
Luminescence
magnetic-luminescent composites
Microscopy
Nanocomposites
Nanocrystals
Nanoparticles
Optical properties
Photoluminescence
Photons
Quantum dots
Solvents
Spectrum analysis
SPIONs
theranostics
Zinc sulfide
Germany
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Summary:Magnetic-luminescent composites based on semiconductor quantum dots (QDs) and superparamagnetic iron oxide nanoparticles (SPIONs) can serve as a platform combining visualization and therapy. Here, we report the construction of QD-SPION nanocomposites based on synthesized SPIONs and alloyed QDs (CdxZn1−xSeyS1−y)/ZnS solubilized with L-cysteine molecules. The study of the spectral-luminescence characteristics, the kinetics of luminescence decay show the composite’s stability in a solution. After incubation with HeLa cells, QDs, SPIONs, and their composites form clusters on the cell surface and associate with endosomes inside the cells. Component-wise analysis of the photoluminescence decay of cell-associated QDs/SPIONs provides information about their localization and aggregate status.
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These authors contributed equally to this work.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23074061