Effect of peripheral lipopolysaccharide injection on dopamine content in murine anterior olfactory nucleus

• Published in: Journal of Neural Transmission Vol. 110; no. 1; pp. 31 - 50
• Main Authors: MORI, K, KANEKO, Y. S, NAKASHIMA, A, FUJIWARA, K, NAGATSU, I, OTA, A
• Format: Journal Article
• Language: English
• Published: Wien Springer 2003; New York, NY Springer Nature B.V
• Subjects: Animals; Base Sequence; Biological and medical sciences; Chromatography, High Pressure Liquid; Dopamine - genetics; Dopamine - metabolism; Endotoxins - administration & dosage; Endotoxins - pharmacology; Fundamental and applied biological sciences. Psychology; GTP Cyclohydrolase - genetics; GTP Cyclohydrolase - metabolism; Injections, Intraperitoneal; Lipopolysaccharides - administration & dosage; Lipopolysaccharides - pharmacology; Male; Mice; Mice, Inbred C3H; Molecular Sequence Data; Norepinephrine - metabolism; Olfactory Bulb - drug effects; Olfactory Bulb - enzymology; Olfactory Bulb - metabolism; Olfactory Pathways - drug effects; Olfactory Pathways - metabolism; Olfactory system and olfaction. Gustatory system and gustation; Polymerase Chain Reaction; Receptors, Adrenergic - metabolism; Receptors, Dopamine - metabolism; RNA, Messenger - metabolism; Time Factors; Tyrosine 3-Monooxygenase - genetics; Tyrosine 3-Monooxygenase - metabolism; Vertebrates: nervous system and sense organs; Dopamine; Rodentia; Central nervous system; Olfactory nucleus; Catecholamine; Vertebrata; Mammalia; Olfactory pathway; Mouse; Anterior olfactory nucleus; Neurotransmitter; Lipopolysaccharide; Olfactory bulb; Brain (vertebrata)
• ISSN: 0300-9564; 1435-1463
• DOI: 10.1007/s00702-002-0771-y

Norepinephrine turnover rate in the murine locus coeruleus (LC) is known to be enhanced by the intraperitoneal (i.p.) injection of lipopolysaccharide (LPS). Approximately 40% of LC neurons are also known to project to the olfactory bulb (OB) and the anterior olfactory nucleus (AON). Therefore, we investigated whether an i.p. injection of 500 microg LPS could modulate the catecholamine biosynthesis in these sites in 8-week-old C3H/HeN male mice. Unexpectedly, the content of norepinephrine was not elevated in both sites during 6-h-observation after LPS injection. The contents of dopamine and its metabolites in the AON were highly increased at 4 h after LPS injection, whereas those in the OB were not elevated during 6-h-observation. Although the AON has been considered not to belong to the dopaminergic neuron system, our report is the first to show an elevated dopamine content in the AON under a stressful condition such as endotoxemia.