Radiolabeling of cidofovir with technetium-99m and biodistribution studies

Radiolabeling cidofovir with technetium-99m (99mTc-CDV) is an innovative procedure that enables real-time monitoring of the drug. Essays were performed in vitro, showing high radiolabel stability within 24 h. Blood clearance, biodistribution studies, and scintigraphic images were performed in health...

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Published inBrazilian Journal of Pharmaceutical Sciences Vol. 56
Main Authors Arribada, Raquel Gregorio, Pereira, Nara Caroline, Cardoso, Valbert Nascimento, Cunha Júnior, Armando da Silva, Barros, André Luís Branco de
Format Journal Article
LanguageEnglish
Published Sao Paulo Universidade de Sao Paulo Faculdade de Ciencias 01.01.2020
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Universidade de São Paulo
Subjects
Anticoagulants
Antiviral drugs
Biodistribution
Cidofovir
Deoxyribonucleic acid
DNA
FDA approval
Pharmacokinetics
PHARMACOLOGY & PHARMACY
Plasma
Proteins
Radiotracer
Scintigraphic imaging
Technetium-99m
Viral infections
Brazil
United States > US
Scintigraphic imaging
Cidofovir
Radiotracer
Biodistribution
Technetium-99m
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Summary:Radiolabeling cidofovir with technetium-99m (99mTc-CDV) is an innovative procedure that enables real-time monitoring of the drug. Essays were performed in vitro, showing high radiolabel stability within 24 h. Blood clearance, biodistribution studies, and scintigraphic images were performed in healthy mice in order to evaluate the profile of the drug in vivo. 99mTc-CDV showed biphasic blood circulation time and significant kidney uptake, indicating that 99mTc-CDV is preferentially eliminated by the renal route. Bones also showed important uptake throughout the experiment. In summary, cidofovir was successfully labeled with technetium-99m and might be used in further studies to track the drug.
ISSN:2175-9790
1984-8250
2175-9790
DOI:10.1590/s2175-97902019000418511