A novel redox cycle diverts cells from oncogene-induced senescence into cancer

Igelmann et al. report a novel metabolic cycle, which they name HTC, that converts NADH into the key antioxidant factor NADPH. The HTC is repressed by the tumor suppressors p53 and RB, and this determines whether oncogene-expressing cells undergo senescence (HTCoff) or malignant transformation (HTCo...

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Bibliographic Details
Published inMolecular cell Vol. 81; no. 18; pp. 3672 - 3674
Main Authors Maus, Mate, Serrano, Manuel
Format Journal Article
LanguageEnglish
Published Elsevier Inc 16.09.2021
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Summary:Igelmann et al. report a novel metabolic cycle, which they name HTC, that converts NADH into the key antioxidant factor NADPH. The HTC is repressed by the tumor suppressors p53 and RB, and this determines whether oncogene-expressing cells undergo senescence (HTCoff) or malignant transformation (HTCon). Igelmann et al. report a novel metabolic cycle, which they name HTC, that converts NADH into the key antioxidant factor NADPH. The HTC is repressed by the tumor suppressors p53 and RB, and this determines whether oncogene-expressing cells undergo senescence (HTCoff) or malignant transformation (HTCon).
Bibliography:ObjectType-Article-2
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ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2021.08.023