Novel nanomedicine-based MRI contrast agents for gynecological malignancies
Gynecological cancers result in significant morbidity and mortality in women despite advances in treatment and diagnosis. This is due to detection of the disease in the late stages following metastatic spread in which treatment options become limited and may not result in positive outcomes. In addit...
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| Published in | Advanced drug delivery reviews Vol. 61; no. 10; pp. 795 - 807 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
10.08.2009
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Gynecological cancers result in significant morbidity and mortality in women despite advances in treatment and diagnosis. This is due to detection of the disease in the late stages following metastatic spread in which treatment options become limited and may not result in positive outcomes. In addition, traditional contrast agents are not very effective in detecting primary metastatic tumors and cells due to a lack of specificity and sensitivity of the diagnostic tools, which limits their effectiveness. Recently, the field of nanomedicine-based contrast agents offers a great opportunity to develop highly sophisticated devices that can overcome many traditional hurdles of contrast agents including solubility, cell-specific targeting, toxicities, and immunological responses. These nanomedicine-based contrast agents including liposomes, micelles, dendrimers, multifunctional magnetic polymeric nanohybrids, fullerenes, and nanotubes represent improvements over their traditional counterparts, which can significantly advance the field of molecular imaging. |
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| AbstractList | Gynecological cancers result in significant morbidity and mortality in women despite advances in treatment and diagnosis. This is due to detection of the disease in the late stages following metastatic spread in which treatment options become limited and may not result in positive outcomes. In addition, traditional contrast agents are not very effective in detecting primary metastatic tumors and cells due to a lack of specificity and sensitivity of the diagnostic tools, which limits their effectiveness. Recently, the field of nanomedicine-based contrast agents offers a great opportunity to develop highly sophisticated devices that can overcome many traditional hurdles of contrast agents including solubility, cell-specific targeting, toxicities, and immunological responses. These nanomedicine-based contrast agents including liposomes, micelles, dendrimers, multifunctional magnetic polymeric nanohybrids, fullerenes, and nanotubes represent improvements over their traditional counterparts, which can significantly advance the field of molecular imaging. |
| Author | Nounou, Mohamed Ismail Bikram, Malavosklish Mody, Vicky V. |
| Author_xml | – sequence: 1 givenname: Vicky V. surname: Mody fullname: Mody, Vicky V. – sequence: 2 givenname: Mohamed Ismail surname: Nounou fullname: Nounou, Mohamed Ismail – sequence: 3 givenname: Malavosklish surname: Bikram fullname: Bikram, Malavosklish email: mbikram@central.uh.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19427886$$D View this record in MEDLINE/PubMed |
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| Keywords | Dendrimers MRI Cervical Gadofullerenes Breast Ovarian Liposomes Gynecological malignancy Magnetoliposomes |
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| SubjectTerms | Breast Breast Neoplasms - diagnosis Cervical Contrast Media - administration & dosage Contrast Media - chemistry Dendrimers Drug Delivery Systems Female Gadofullerenes Gynecological malignancy Humans Liposomes Magnetic Resonance Imaging - methods Magnetoliposomes MRI Nanostructures Ovarian Ovarian Neoplasms - diagnosis Uterine Cervical Neoplasms - diagnosis |
| Title | Novel nanomedicine-based MRI contrast agents for gynecological malignancies |
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