Novel nanomedicine-based MRI contrast agents for gynecological malignancies

Gynecological cancers result in significant morbidity and mortality in women despite advances in treatment and diagnosis. This is due to detection of the disease in the late stages following metastatic spread in which treatment options become limited and may not result in positive outcomes. In addit...

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Published inAdvanced drug delivery reviews Vol. 61; no. 10; pp. 795 - 807
Main Authors Mody, Vicky V., Nounou, Mohamed Ismail, Bikram, Malavosklish
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 10.08.2009
Subjects
Breast
Breast Neoplasms - diagnosis
Cervical
Contrast Media - administration & dosage
Contrast Media - chemistry
Dendrimers
Drug Delivery Systems
Female
Gadofullerenes
Gynecological malignancy
Humans
Liposomes
Magnetic Resonance Imaging - methods
Magnetoliposomes
MRI
Nanostructures
Ovarian
Ovarian Neoplasms - diagnosis
Uterine Cervical Neoplasms - diagnosis
Dendrimers
MRI
Cervical
Gadofullerenes
Breast
Ovarian
Liposomes
Gynecological malignancy
Magnetoliposomes
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Summary:Gynecological cancers result in significant morbidity and mortality in women despite advances in treatment and diagnosis. This is due to detection of the disease in the late stages following metastatic spread in which treatment options become limited and may not result in positive outcomes. In addition, traditional contrast agents are not very effective in detecting primary metastatic tumors and cells due to a lack of specificity and sensitivity of the diagnostic tools, which limits their effectiveness. Recently, the field of nanomedicine-based contrast agents offers a great opportunity to develop highly sophisticated devices that can overcome many traditional hurdles of contrast agents including solubility, cell-specific targeting, toxicities, and immunological responses. These nanomedicine-based contrast agents including liposomes, micelles, dendrimers, multifunctional magnetic polymeric nanohybrids, fullerenes, and nanotubes represent improvements over their traditional counterparts, which can significantly advance the field of molecular imaging.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2009.04.020