Gold nanocages as contrast agents for spectroscopic optical coherence tomography

We describe gold nanocages as a new class of potential contrast agent for spectroscopic optical coherence tomography (OCT). Monodispersed gold nanocages of an approximately 35 nm edge length exhibit strong optical resonance, with the peak wavelength tunable in the near-infrared range. We characteriz...

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Bibliographic Details
Published inOptics letters Vol. 30; no. 22; p. 3048
Main Authors Cang, Hu, Sun, Tao, Li, Zhi-Yuan, Chen, Jingyi, Wiley, Benjamin J, Xia, Younan, Li, Xingde
Format Journal Article
LanguageEnglish
Published United States 15.11.2005
Subjects
Contrast Media
Image Enhancement - methods
Nanostructures - chemistry
Nanostructures - ultrastructure
Particle Size
Reproducibility of Results
Sensitivity and Specificity
Tomography, Optical Coherence - methods
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Summary:We describe gold nanocages as a new class of potential contrast agent for spectroscopic optical coherence tomography (OCT). Monodispersed gold nanocages of an approximately 35 nm edge length exhibit strong optical resonance, with the peak wavelength tunable in the near-infrared range. We characterized the optical properties of the nanocage by using OCT experiments along with numerical calculations, revealing an absorption cross section approximately 5 orders of magnitude larger than conventional dyes. Experiments with tissue phantoms demonstrated that the nanocages provide enhanced contrast for spectroscopic as well as conventional intensity-based OCT imaging.
ISSN:0146-9592
DOI:10.1364/ol.30.003048